ARTICLES

Cancer Chronotherapy & e-Health
  • Komarzynski S, Huang Q, Innominato PF, Maurice M, Arbaud A, Beau J, Bouchahda  M, Ulusakarya A, Beaumatin N, Breda G, Finkenstädt B, Levi F. Inter-subject differences in circadian coordination captured in real time in healthy and cancerous individual persons during their daily routine using a mobile internet platform. J Med Internet Res. 2018 Jan 5. doi: 10.2196/jmir.9779. [Epub ahead of  print] PubMed PMID: 29704408.  
  • Zhang Y, Lévi F, Chang Y. Chronotherapy with defective circadian clock? Aging  (Albany NY). 2018 Apr 24;10(4):520-521. doi: 10.18632/aging.101430. PubMed PMID:  29695639. 
  • Huang Q, Cohen D, Komarzynski S, Li XM, Innominato P, Lévi F, Finkenstädt B. Hidden Markov models for monitoring circadian rhythmicity in telemetric activity  data. J R Soc Interface. 2018 Feb;15(139). pii: 20170885. doi: 10.1098/rsif.2017.0885. PubMed PMID: 29436510; PubMed Central PMCID: PMC5832732. 
  • Ozturk N, Ozturk D, Pala-Kara Z, Kaptan E, Sancar-Bas S, Ozsoy N, Cinar S, Deniz G, Li XM, Giacchetti S, Lévi F, Okyar A. The immune system as a chronotoxicity target of the anticancer mTOR inhibitor everolimus. Chronobiol Int. 2018 Feb 5:1-14. doi: 10.1080/07420528.2018.1432632. [Epub ahead of print] PubMed PMID: 29400578.
  • Zhang Y, Giacchetti S, Parouchev A, Hadadi E, Li X, Dallmann R, Xandri-Monje H, Portier L, Adam R, Lévi F, Dulong S, Chang Y. Dosing time dependent in vitro pharmacodynamics of Everolimus despite a defective circadian clock. Cell Cycle. 2018;17(1):33-42. doi: 10.1080/15384101.2017.1387695. Epub 2018 Jan 2. PubMed PMID: 29099263; PubMed Central PMCID: PMC5815427. 
  • Lévi F, Karaboué A, Saffroy R, Desterke C, Boige V, Smith D, Hebbar M, Innominato P, Taieb J, Carvalho C, Guimbaud R, Focan C, Bouchahda M, Adam R, Ducreux M, Milano G, Lemoine A. Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228). Br J Cancer. 2017 Sep 26;117(7):965-973. doi: 10.1038/bjc.2017.278. Epub 2017 Aug 17. PubMed PMID:  28817838; PubMed Central PMCID: PMC5625679.  
  • Palesh O, Haitz K, Lévi F, Bjarnason GA, Deguzman C, Alizeh I, Ulusakarya A,  Packer MM, Innominato PF. Relationship between subjective and actigraphy-measured sleep in 237 patients with metastatic colorectal cancer. Qual Life Res. 2017 Oct;26(10):2783-2791. doi: 10.1007/s11136-017-1617-2. Epub 2017 Jun 27. PubMed PMID: 28656534; PubMed Central PMCID: PMC5711611.  
  • Ballesta A, Innominato PF, Dallmann R, Rand DA, Lévi FA. Systems Chronotherapeutics. Pharmacol Rev. 2017 Apr;69(2):161-199. doi: 10.1124/pr.116.013441. Review. PubMed PMID: 28351863; PubMed Central PMCID: PMC5394920.  
  • Mteyrek A, Filipski E, Guettier C, Oklejewicz M, van der Horst GT, Okyar A, Lévi F. Critical cholangiocarcinogenesis control by cryptochrome clock genes. Int J Cancer. 2017 Jun 1;140(11):2473-2483. doi: 10.1002/ijc.30663. Epub 2017 Mar 16. PubMed PMID: 28224616. 
  • Innominato PF, Komarzynski S, Mohammad-Djafari A, Arbaud A, Ulusakarya A, Bouchahda M, Haydar M, Bossevot-Desmaris R, Plessis V, Mocquery M, Bouchoucha D,  Afshar M, Beau J, Karaboué A, Morère JF, Fursse J, Rovira Simon J, Levi F. Clinical Relevance of the First Domomedicine Platform Securing Multidrug Chronotherapy Delivery in Metastatic Cancer Patients at Home: The inCASA European Project. J Med Internet Res. 2016 Nov 25;18(11):e305. PubMed PMID: 27888171; PubMed Central PMCID: PMC5148811.  
  • Bouchahda M, Boige V, Smith D, Karaboué A, Ducreux M, Hebbar M, Lepère C, Focan C, Guimbaud R, Innominato P, Awad S, Carvalho C, Tumolo S, Truant S, De Baere T, Castaing D, Rougier P, Morère JF, Taieb J, Adam R, Lévi F; ARTBC International. Early tumour response as a survival predictor in previously- treated patients receiving triplet hepatic artery infusion and intravenous cetuximab for unresectable liver metastases from wild-type KRAS colorectal cancer. Eur J Cancer. 2016 Nov;68:163-172. doi: 10.1016/j.ejca.2016.09.011. Epub  2016 Oct 18. PubMed PMID: 27768923. 
  • Mteyrek A, Filipski E, Guettier C, Okyar A, Lévi F. Clock gene Per2 as a controller of liver carcinogenesis. Oncotarget. 2016 Dec 27;7(52):85832-85847. doi: 10.18632/oncotarget.11037. PubMed PMID: 27494874; PubMed Central PMCID: PMC5349878.  
  • Bishehsari F, Levi F, Turek FW, Keshavarzian A. Circadian Rhythms in Gastrointestinal Health and Diseases. Gastroenterology. 2016 Sep;151(3):e1-5. doi: 10.1053/j.gastro.2016.07.036. Epub 2016 Jul 29. PubMed PMID: 27480174; PubMed Central PMCID: PMC5002365. 
  • Lévi F, Karaboué A, Etienne-Grimaldi MC, Paintaud G, Focan C, Innominato P, Bouchahda M, Milano G, Chatelut E. Pharmacokinetics of Irinotecan, Oxaliplatin and 5-Fluorouracil During Hepatic Artery Chronomodulated Infusion: A Translational European OPTILIV Study. Clin Pharmacokinet. 2017 Feb;56(2):165-177. doi: 10.1007/s40262-016-0431-2. PubMed PMID: 27393140.  
  • Ortiz-Tudela E, Innominato PF, Rol MA, Lévi F, Madrid JA. Relevance of internal time and circadian robustness for cancer patients. BMC Cancer. 2016 Apr  21;16:285. doi: 10.1186/s12885-016-2319-9. PubMed PMID: 27102330; PubMed Central  PMCID: PMC4839139.  
  • Dallmann R, Okyar A, Lévi F. Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy. Trends Mol Med. 2016 May;22(5):430-445. doi: 10.1016/j.molmed.2016.03.004. Epub 2016 Apr 5. Review. PubMed PMID: 27066876.  
  • Lévi FA, Boige V, Hebbar M, Smith D, Lepère C, Focan C, Karaboué A, Guimbaud  R, Carvalho C, Tumolo S, Innominato P, Ajavon Y, Truant S, Castaing D, De Baere T, Kunstlinger F, Bouchahda M, Afshar M, Rougier P, Adam R, Ducreux M; Association Internationale pour Recherche sur Temps Biologique et Chronothérapie  (ARTBC International). Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV. Ann Oncol. 2016 Feb;27(2):267-74. doi: 10.1093/annonc/mdv548. Epub 2015 Nov 16. PubMed PMID: 26578731.   
  • Natale V, Innominato PF, Boreggiani M, Tonetti L, Filardi M, Parganiha A, Fabbri M, Martoni M, Lévi F. The difference between in bed and out of bed activity as a behavioral marker of cancer patients: A comparative actigraphic study. Chronobiol Int. 2015;32(7):925-33. doi:10.3109/07420528.2015.1053909. PubMed PMID: 26158757.  
  • Dulong S, Ballesta A, Okyar A, Lévi F. Identification of Circadian Determinants of Cancer Chronotherapy through In Vitro Chronopharmacology and Mathematical Modeling. Mol Cancer Ther. 2015 Sep;14(9):2154-64. doi: 10.1158/1535-7163.MCT-15-0129. Epub 2015 Jul 3. PubMed PMID: 26141947.  
  • Feillet C, van der Horst GT, Levi F, Rand DA, Delaunay F. Coupling between the Circadian Clock and Cell Cycle Oscillators: Implication for Healthy Cells and Malignant Growth. Front Neurol. 2015 May 11;6:96. doi: 10.3389/fneur.2015.00096.  eCollection 2015. Review. PubMed PMID: 26029155; PubMed Central PMCID: PMC4426821.  
  • Sallam H, El-Serafi AT, Filipski E, Terelius Y, Lévi F, Hassan M. The effect  of circadian rhythm on pharmacokinetics and metabolism of the Cdk inhibitor, roscovitine, in tumor mice model. Chronobiol Int. 2015 Jun;32(5):608-14. doi: 10.3109/07420528.2015.1022782. Epub 2015 May 4. PubMed PMID: 25938685.  
  • Innominato PF, Spiegel D, Ulusakarya A, Giacchetti S, Bjarnason GA, Lévi F, Palesh O. Subjective sleep and overall survival in chemotherapy-naïve patients with metastatic colorectal cancer. Sleep Med. 2015 Mar;16(3):391-8. doi: 10.1016/j.sleep.2014.10.022. Epub 2015 Jan 22. PubMed PMID: 25678361. 
  • Feillet C, Krusche P, Tamanini F, Janssens RC, Downey MJ, Martin P, Teboul M, Saito S, Lévi FA, Bretschneider T, van der Horst GT, Delaunay F, Rand DA. Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9828-33. doi: 10.1073/pnas.1320474111. Epub 2014 Jun 23. PubMed PMID: 24958884; PubMed Central  PMCID: PMC4103330.  
  • Lévi F, Dugué PA, Innominato P, Karaboué A, Dispersyn G, Parganiha A, Giacchetti S, Moreau T, Focan C, Waterhouse J, Spiegel D; ARTBC Chronotherapy Group. Wrist actimetry circadian rhythm as a robust predictor of colorectal cancer patients survival. Chronobiol Int. 2014 Oct;31(8):891-900. doi: 10.3109/07420528.2014.924523. Epub 2014 Jun 13. PubMed PMID: 24927369.  
  • Innominato PF, Roche VP, Palesh OG, Ulusakarya A, Spiegel D, Lévi FA. The circadian timing system in clinical oncology. Ann Med. 2014 Jun;46(4):191-207. doi: 10.3109/07853890.2014.916990. Review. PubMed PMID: 24915535.  
  • Siffroi-Fernandez S, Dulong S, Li XM, Filipski E, Gréchez-Cassiau A, Peteri-Brünback B, Meijer L, Lévi F, Teboul M, Delaunay F. Functional genomics identify Birc5/survivin as a candidate gene involved in the chronotoxicity of cyclin-dependent kinase inhibitors. Cell Cycle. 2014;13(6):984-91. doi: 10.4161/cc.27868. Epub 2014 Jan 21. PubMed PMID: 24552823; PubMed Central PMCID:  PMC3984321.  
  • Ortiz-Tudela E, Iurisci I, Beau J, Karaboue A, Moreau T, Rol MA, Madrid JA, Lévi F, Innominato PF. The circadian rest-activity rhythm, a potential safety pharmacology endpoint of cancer chemotherapy. Int J Cancer. 2014 Jun 1;134(11):2717-25. doi: 10.1002/ijc.28587. Epub 2013 Nov 25. PubMed PMID: 24510611. 
  • Roche VP, Mohamad-Djafari A, Innominato PF, Karaboué A, Gorbach A, Lévi FA. Thoracic surface temperature rhythms as circadian biomarkers for cancer chronotherapy. Chronobiol Int. 2014 Apr;31(3):409-20. doi: 10.3109/07420528.2013.864301. Epub 2014 Jan 7. PubMed PMID: 24397341; PubMed Central PMCID: PMC4221267.  
  • Filipski E, Berland E, Ozturk N, Guettier C, van der Horst GT, Lévi F, Okyar  A. Optimization of irinotecan chronotherapy with P-glycoprotein inhibition. Toxicol Appl Pharmacol. 2014 Feb 1;274(3):471-9. doi: 10.1016/j.taap.2013.12.018. Epub 2013 Dec 29. PubMed PMID: 24380837.  
  • Li XM, Mohammad-Djafari A, Dumitru M, Dulong S, Filipski E, Siffroi-Fernandez S, Mteyrek A, Scaglione F, Guettier C, Delaunay F, Lévi F. A circadian clock transcription model for the personalization of cancer chronotherapy. Cancer Res.  2013 Dec 15;73(24):7176-88. doi: 10.1158/0008-5472.CAN-13-1528. Epub 2013 Oct 23. PubMed PMID: 24154875. 
  • Costa MJ, Finkenstädt B, Roche V, Lévi F, Gould PD, Foreman J, Halliday K, Hall A, Rand DA. Inference on periodicity of circadian time series. Biostatistics. 2013 Sep;14(4):792-806. doi: 10.1093/biostatistics/kxt020. Epub 2013 Jun 6. PubMed PMID: 23743206; PubMed Central PMCID: PMC3988453.  
  • Innominato PF, Giacchetti S, Moreau T, Bjarnason GA, Smaaland R, Focan C, Garufi C, Iacobelli S, Tampellini M, Tumolo S, Carvalho C, Karaboué A, Poncet A,  Spiegel D, Lévi F; International Association for Research on Time in Biology and  Chronotherapy (ARTBC) Chronotherapy Group. Fatigue and weight loss predict survival on circadian chemotherapy for metastatic colorectal cancer. Cancer. 2013 Jul 15;119(14):2564-73. doi: 10.1002/cncr.28072. Epub 2013 Apr 30. PubMed PMID: 23633399.  
  • Ortiz-Tudela E, Mteyrek A, Ballesta A, Innominato PF, Lévi F. Cancer chronotherapeutics: experimental, theoretical, and clinical aspects. Handb Exp Pharmacol. 2013;(217):261-88. doi: 10.1007/978-3-642-25950-0_11. Review. PubMed PMID: 23604483.  
  • Giacchetti S, Dugué PA, Innominato PF, Bjarnason GA, Focan C, Garufi C, Tumolo S, Coudert B, Iacobelli S, Smaaland R, Tampellini M, Adam R, Moreau T, Lévi F; ARTBC International Chronotherapy Group. Sex moderates circadian chemotherapy effects on survival of patients with metastatic colorectal cancer: a meta-analysis. Ann Oncol. 2012 Dec;23(12):3110-6. doi: 10.1093/annonc/mds148. Epub 2012 Jun 27. PubMed PMID: 22745214.  
  • Innominato PF, Giacchetti S, Bjarnason GA, Focan C, Garufi C, Coudert B, Iacobelli S, Tampellini M, Durando X, Mormont MC, Waterhouse J, Lévi FA. Prediction of overall survival through circadian rest-activity monitoring during chemotherapy for metastatic colorectal cancer. Int J Cancer. 2012 Dec 1;131(11):2684-92. doi: 10.1002/ijc.27574. Epub 2012 Jul 3. PubMed PMID: 22488038.   
  • Altinok A, Gonze D, Lévi F, Goldbeter A. An automaton model for the cell cycle. Interface Focus. 2011 Feb 6;1(1):36-47. doi: 10.1098/rsfs.2010.0009. Epub  2010 Nov 24. PubMed PMID: 22419973; PubMed Central PMCID: PMC3262245.  
  • Lévi F, Okyar A. Circadian clocks and drug delivery systems: impact and opportunities in chronotherapeutics. Expert Opin Drug Deliv. 2011 Dec;8(12):1535-41. doi: 10.1517/17425247.2011.618184. PubMed PMID: 22097903. 
  • Ballesta A, Dulong S, Abbara C, Cohen B, Okyar A, Clairambault J, Levi F. A  combined experimental and mathematical approach for molecular-based optimization  of irinotecan circadian delivery. PLoS Comput Biol. 2011 Sep;7(9):e1002143. doi:  10.1371/journal.pcbi.1002143. Epub 2011 Sep 8. PubMed PMID: 21931543; PubMed Central PMCID: PMC3169519.  
  • Innominato PF, Giacchetti S, Moreau T, Smaaland R, Focan C, Bjarnason GA, Garufi C, Iacobelli S, Tampellini M, Tumolo S, Carvalho C, Karaboué A, Lévi F; ARTBC International Chronotherapy Group. Prediction of survival by neutropenia according to delivery schedule of oxaliplatin-5-Fluorouracil-leucovorin for metastatic colorectal cancer in a randomized international trial (EORTC 05963). Chronobiol Int. 2011 Aug;28(7):586-600. doi: 10.3109/07420528.2011.597532. PubMed PMID: 21859417.  
  • Bouchahda M, Lévi F, Adam R, Rougier P. Modern insights into hepatic arterial infusion for liver metastases from colorectal cancer. Eur J Cancer. 2011 Dec;47(18):2681-90. doi: 10.1016/j.ejca.2011.06.037. Epub 2011 Jul 21. Review. PubMed PMID: 21783358.  
  • Ahowesso C, Li XM, Zampera S, Peteri-Brunbäck B, Dulong S, Beau J, Hossard V, Filipski E, Delaunay F, Claustrat B, Lévi F. Sex and dosing-time dependencies  in irinotecan-induced circadian disruption. Chronobiol Int. 2011 May;28(5):458-70. doi: 10.3109/07420528.2011.569043. PubMed PMID: 21721861. 
  • Okyar A, Piccolo E, Ahowesso C, Filipski E, Hossard V, Guettier C, La Sorda  R, Tinari N, Iacobelli S, Lévi F. Strain- and sex-dependent circadian changes in  abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum. PLoS One. 2011;6(6):e20393. doi: 10.1371/journal.pone.0020393. Epub  2011 Jun 3. PubMed PMID: 21674030; PubMed Central PMCID: PMC3108586. 
  •  Scully CG, Karaboué A, Liu WM, Meyer J, Innominato PF, Chon KH, Gorbach AM,  Lévi F. Skin surface temperature rhythms as potential circadian biomarkers for personalized chronotherapeutics in cancer patients. Interface Focus. 2011 Feb 6;1:48-60. PubMed PMID: 21544221; PubMed Central PMCID: PMC3085452.  
  • Bouchahda M, Macarulla T, Liedo G, Lévi F, Elez ME, Paule B, Karaboué A, Artru P, Tabernero J, Machover D, Innominato P, Goldschmidt E, Bonnet D, Ducreux  M, Castagne V, Guimbaud R. Feasibility of cetuximab given with a simplified schedule every 2 weeks in advanced colorectal cancer: a multicenter, retrospective analysis. Med Oncol. 2011 Dec;28 Suppl 1:S253-8. doi: 10.1007/s12032-010-9716-8. Epub 2010 Nov 5. PubMed PMID: 21053102. 
  • Wicherts DA, de Haas RJ, Sebagh M, Ciacio O, Lévi F, Paule B, Giacchetti S,  Guettier C, Azoulay D, Castaing D, Adam R. Regenerative nodular hyperplasia of the liver related to chemotherapy: impact on outcome of liver surgery for colorectal metastases. Ann Surg Oncol. 2011 Mar;18(3):659-69. doi: 10.1245/s10434-010-1385-5. Epub 2010 Oct 26. PubMed PMID: 20976564; PubMed Central PMCID: PMC3044234.  
  • Innominato PF, Palesh O, Dhabhar FS, Lévi F, Spiegel D. Regulation of circadian rhythms and hypothalamic-pituitary-adrenal axis: an overlooked interaction in cancer. Lancet Oncol. 2010 Sep;11(9):816-7. doi: 10.1016/S1470-2045(10)70171-6. PubMed PMID: 20816374.  
  • Rajnai Z, Méhn D, Beéry E, Okyar A, Jani M, Tóth GK, Fülöp F, Lévi F, Krajcsi P. ATP-binding cassette B1 transports seliciclib (R-roscovitine), a cyclin-dependent kinase inhibitor. Drug Metab Dispos. 2010 Nov;38(11):2000-6. doi: 10.1124/dmd.110.032805. Epub 2010 Aug 10. PubMed PMID: 20699410. 
  • Innominato PF, Lévi FA, Bjarnason GA. Chronotherapy and the molecular clock: Clinical implications in oncology. Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):979-1001. doi: 10.1016/j.addr.2010.06.002. Epub 2010 Jun 23. Review.  PubMed PMID: 20600409.  
  • Lévi F, Karaboué A, Gorden L, Innominato PF, Saffroy R, Giacchetti S, Hauteville D, Guettier C, Adam R, Bouchahda M. Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability. Cancer Chemother Pharmacol. 2011 Feb;67(2):339-48. doi: 10.1007/s00280-010-1327-8. Epub 2010 Apr 17. PubMed PMID: 20401611.  
  • Li XM, Delaunay F, Dulong S, Claustrat B, Zampera S, Fujii Y, Teboul M, Beau J, Lévi F. Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing. Cancer Res. 2010 Apr 15;70(8):3351-60. doi: 10.1158/0008-5472.CAN-09-4235. PubMed PMID: 20395208.  
  • Bouchahda M, Karaboué A, Saffroy R, Innominato P, Gorden L, Guettier C, Adam R, Lévi F. Acquired KRAS mutations during progression of colorectal cancer metastases: possible implications for therapy and prognosis. Cancer Chemother Pharmacol. 2010 Aug;66(3):605-9. doi: 10.1007/s00280-010-1298-9. Epub 2010 Apr 2. PubMed PMID: 20361188.  
  • Bernard S, Cajavec Bernard B, Lévi F, Herzel H. Tumor growth rate determines the timing of optimal chronomodulated treatment schedules. PLoS Comput Biol. 2010 Mar 19;6(3):e1000712. doi: 10.1371/journal.pcbi.1000712. PubMed PMID: 20333244; PubMed Central PMCID: PMC2841621.  
  • Lévi F, Okyar A, Dulong S, Innominato PF, Clairambault J. Circadian timing in cancer treatments. Annu Rev Pharmacol Toxicol. 2010;50:377-421. doi: 10.1146/annurev.pharmtox.48.113006.094626. Review. PubMed PMID: 20055686.  
  • de Haas RJ, Wicherts DA, Flores E, Ducreux M, Lévi F, Paule B, Azoulay D, Castaing D, Lemoine A, Adam R. Tumor marker evolution: comparison with imaging for assessment of response to chemotherapy in patients with colorectal liver metastases. Ann Surg Oncol. 2010 Apr;17(4):1010-23. doi: 10.1245/s10434-009-0887-5. Epub 2010 Jan 6. PubMed PMID: 20052553; PubMed Central PMCID: PMC2840671.  
  • Innominato PF, Mormont MC, Rich TA, Waterhouse J, Lévi FA, Bjarnason GA. Circadian disruption, fatigue, and anorexia clustering in advanced cancer patients: implications for innovative therapeutic approaches. Integr Cancer Ther. 2009 Dec;8(4):361-70. Review. PubMed PMID: 20050374.  
  • Filipski E, Lévi F. Circadian disruption in experimental cancer processes. Integr Cancer Ther. 2009 Dec;8(4):298-302. doi: 10.1177/1534735409352085. PubMed  PMID: 20042408.  
  • Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE Jr, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan 1;70(1):12-3. doi: 10.1158/0008-5472.CAN-09-2676. Epub 2009 Dec 22. PubMed PMID:  20028868; PubMed Central PMCID: PMC2802734.  
  • Ahowesso C, Piccolo E, Li XM, Dulong S, Hossard V, La Sorda R, Filipski E, Tinari N, Delaunay F, Iacobelli S, Lévi F. Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice. Toxicol Lett. 2010 Feb 15;192(3):395-401. doi: 10.1016/j.toxlet.2009.11.017. Epub 2009 Nov 29. PubMed PMID: 19931604.  
  • Iurisci I, Filipski E, Sallam H, Harper F, Guettier C, Maire I, Hassan M, Iacobelli S, Lévi F. Liver circadian clock, a pharmacologic target of cyclin-dependent kinase inhibitor seliciclib. Chronobiol Int. 2009 Aug;26(6):1169-88. doi: 10.3109/07420520903209942. PubMed PMID: 19731111.  
  • Bouchahda M, Adam R, Giacchetti S, Castaing D, Brezault-Bonnet C, Hauteville D, Innominato PF, Focan C, Machover D, Lévi F. Rescue chemotherapy using multidrug chronomodulated hepatic arterial infusion for patients with heavily pretreated metastatic colorectal cancer. Cancer. 2009 Nov 1;115(21):4990-9. doi:  10.1002/cncr.24549. PubMed PMID: 19637365.  
  • Innominato PF, Focan C, Gorlia T, Moreau T, Garufi C, Waterhouse J, Giacchetti S, Coudert B, Iacobelli S, Genet D, Tampellini M, Chollet P, Lentz MA, Mormont MC, Lévi F, Bjarnason GA; Chronotherapy Group of the European Organization for Research and Treament of Cancer. Circadian rhythm in rest and activity: a biological correlate of quality of life and a predictor of survival in patients with metastatic colorectal cancer. Cancer Res. 2009 Jun 1;69(11):4700-7. doi: 10.1158/0008-5472.CAN-08-4747. PubMed PMID: 19470769; PubMed Central PMCID: PMC2690615. 
  • Adam R, Wicherts DA, de Haas RJ, Ciacio O, Lévi F, Paule B, Ducreux M, Azoulay D, Bismuth H, Castaing D. Patients with initially unresectable colorectal liver metastases: is there a possibility of cure? J Clin Oncol. 2009 Apr 10;27(11):1829-35. doi: 10.1200/JCO.2008.19.9273. Epub 2009 Mar 9. PubMed PMID: 19273699. 
  • Altinok A, Lévi F, Goldbeter A. Identifying mechanisms of chronotolerance and chronoefficacy for the anticancer drugs 5-fluorouracil and oxaliplatin by computational modeling. Eur J Pharm Sci. 2009 Jan 31;36(1):20-38. doi: 10.1016/j.ejps.2008.10.024. Epub 2008 Nov 11. Review. PubMed PMID: 19041394.  
  • Coudert B, Focan C, Genet D, Giacchetti S, Cvickovic F, Zambelli A, Fillet G, Chollet P, Amoroso D, Van Der Auwera J, Lentz MA, Marreaud S, Baron B, Gorlia  T, Biville F, Lévi F. A randomized multicenter study of optimal circadian time of vinorelbine combined with chronomodulated 5-fluorouracil in pretreated metastatic breast cancer patients: EORTC trial 05971. Chronobiol Int. 2008 Sep;25(5):680-96. doi: 10.1080/07420520802384036. PubMed PMID: 18780198.  
  • Lévi F. [The circadian-timing system: a determinant of drug activity and a target of anticancer treatments]. Ann Pharm Fr. 2008 Jun;66(3):175-84. doi: 10.1016/j.pharma.2008.05.003. Review. French. PubMed PMID: 18706346.  
  • Lévi F, Altinok A, Clairambault J, Goldbeter A. Implications of circadian clocks for the rhythmic delivery of cancer therapeutics. Philos Trans A Math Phys Eng Sci. 2008 Oct 13;366(1880):3575-98. doi: 10.1098/rsta.2008.0114. Review. Erratum in: Philos Transact A Math Phys Eng Sci. 2008 Dec 28;366(1885):4665-6. PubMed PMID: 18644767.  
  • Efficace F, Innominato PF, Bjarnason G, Coens C, Humblet Y, Tumolo S, Genet  D, Tampellini M, Bottomley A, Garufi C, Focan C, Giacchetti S, Lévi F; Chronotherapy Group of the European Organisation for Research and Treatment of Cancer. Validation of patient's self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer. J Clin Oncol. 2008 Apr 20;26(12):2020-6. doi: 10.1200/JCO.2007.12.3117. PubMed PMID: 18421055.  
  • Lévi F, Filipski E, Iurisci I, Li XM, Innominato P. Cross-talks between circadian timing system and cell division cycle determine cancer biology and therapeutics. Cold Spring Harb Symp Quant Biol. 2007;72:465-75. doi: 10.1101/sqb.2007.72.030. Review. PubMed PMID: 18419306. 
  • Dulong S, Delaunay F, Lévi F. [Circadian control of muscle transcriptome]. Med Sci (Paris). 2008 Apr;24(4):372-4. doi: 10.1051/medsci/2008244372. French. PubMed PMID: 18405635.  
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  • Adam R, Wicherts DA, de Haas RJ, Aloia T, Lévi F, Paule B, Guettier C, Kunstlinger F, Delvart V, Azoulay D, Castaing D. Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: myth or reality? J Clin Oncol. 2008 Apr 1;26(10):1635-41. doi: 10.1200/JCO.2007.13.7471. PubMed PMID: 18375892.   
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Optimisation of Post-operative Hepatic Functions
Mathematical modeling for personalized cancer medicine

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